Wednesday, February 27, 2008
When the heck should we take our synthroid?
~~Research reported in the journal, Clinical Endocrinology, did find that taking the same dose of levothyroxine at bedtime, as compared to first thing in the morning, might be better.
A small pilot study was prompted by observation that some patients had improved thyroid hormone profiles after they switched from taking their levothyroxine in the morning, to bedtime.
The study, while small (12 subjects), was fairly conclusive in its findings, which the researchers said were "striking" and which have "important consequences for the millions of patients who take l-thyroxine daily."
Researchers reported that taking medication at bedtime, rather than the morning, results in "higher thyroid hormone concentrations and lower TSH concentrations." TSH decreased and Free T4 levels rose in all patients by changing thyroxine ingestion from early morning to bedtime and T3 levels rose in all but one subject. And TSH decreased irrespective of the starting TSH levels, suggesting better absorption of the thyroid medication when taken in the evening. Interestingly, the researchers found that the circadian TSH rhythm -- the typical daily fluctuations of TSH that occur during a 24-hour period -- does not vary.
The researchers suggested several explanations for the results:
Even when waiting at least 30 minutes to eat, breakfast may be interfering with the intestinal absorption of thyroid medication
"Bowel motility is slower at night," which means that it takes longer for the levothyroxine tablet to transit through the intestinal system, resulting in longer exposure to the intestinal wall, and therefore, better uptake of the medication.
The conversion process of T4 to T3 may be more effective in the evening. The researchers have suggested that given the results of this pilot study, a large double-blinded randomized study will need to be performed to confirm their results.
You may want to talk to your practitioner about changing the time you take your medication to bedtime, versus morning. And if you decide to change to taking your thyroid medication in the evening, be sure to have your thyroid levels evaluated -- six to eight weeks is a reasonable timeframe -- after you've made the switch.~~
Sunday, February 24, 2008
Friday, February 22, 2008
Sunday, February 17, 2008
Saturday, February 16, 2008
Thursday, February 14, 2008
True or False: In the Middle Ages, young men and women drew names from a bowl to see who their valentines would be. They would wear these names on their sleeves for one week. To wear your heart on your sleeve now means that it is easy for other people to know how you are feeling.
True or False: Some people used to believe that if a woman saw a robin flying overhead on Valentine's Day, it meant she would marry a sailor. If she saw a sparrow, she would marry a poor man and be very happy. If she saw a goldfinch, she would marry a millionaire.
True or False: 85% of all valentines are purchased by women.
If you answered true to all three, you are correct.
~~~Love letters throughout the year are often signed with a string of "X's" to represent kisses. Why? Our practice of using an "X" grew out of the Medieval practive of letting those who could not write, mark documents with an "X" to represent their names. This was done in the presence of Witnesses and a kiss was given upon the "X:" to show sincerity. The "X" then became synonomous with the kiss in the minds of most people. There are two possible explanations why an "X" was chosen to represent one's name. One explanation is that the "X" shape was originally thought of as a cross. This "X" shaped cross was the symbol of St. Andrew. It may have been that people were making a pledge in the name of the Saint. The second explanation is that it may have been a plege in the name of Christ. The "X", or chi symbol is also a letter of the Greek alphabet, which has also been used to represent the name of Christ.~~~
Doughboy was buried in a lightly greased coffin. Dozens of celebrities turned out to pay their respects, including Mrs. Butterworth, Hungry Jack,the California Raisins, Betty Crocker, the Hostess Twinkies, and CaptainCrunch. The grave site was piled high with flours.'
Aunt Jemima delivered the eulogy and lovingly described the Doughboy as a man who never knew how much he was kneaded. Doughboy rose quickly in showbusiness, but his later life was filled with turnovers. He was not considered a very smart cookie, wasting much of his dough on half-baked schemes. Despite being a little flaky at times, he was still a crusty oldman and was considered a positive roll model for millions.
Doughboy is survived by his wife Play Dough, two children, John Dough and Jane Dough, plus they had one in the oven. He is also survived by his elderly father, Pop Tart.The funeral was held at 350 for about 20 minutes.
Monday, February 11, 2008
~~Napoleon Bonaparte did not die from arsenic poisoning, a new examination of the French emperor's hair has established.
The man who dominated much of Europe in the early 19th century died at age 52 in British-imposed exile on St. Helena in the south Atlantic, where he had been banished after his defeat at the Battle of Waterloo.
For decades, scholars have debated how Napoleon met his early death on May 5, 1821.
The autopsy and conclusion of his personal doctor, Francesco Antommarchi, indicated that Napoleon died of stomach cancer.
But the veracity of Antommarchi's report was questioned in 1961, and more recently in 2001, when high arsenic levels were found in Napoleon's hair. Various theories of conspiracy, treachery and poisoning followed.
Now, Italian scientists have repeated the hair testing using a small nuclear reactor. The study will be published in the March issue of the Italian journal Il Saggiatore.~~
Thursday, February 07, 2008
Monday, February 04, 2008
The device is just two molars in size and could ensure that patients take the correct amount of medicine, at precisely the correct time.
Electronic and software components also allow doctors to adjust doses during the course of treatment, as well as track the history of the therapy.
Made of stainless steel and polymers, the IntelliDrug device is comprised of a drug reservoir, a micro-fluidic duct, an electrically controlled valve, sensors, and two batteries. The medication is placed into the reservoir as a solid pill.
Water from saliva passes through a membrane and generates pressure in the drug reservoir. A microcontroller opens a valve and releases the pressurized solution into the mouth at programmed intervals. Meanwhile, a sensor keeps track of the medicine flowing out and monitors the pill as it becomes depleted.
The device can even be controlled by an external remote control, which uses infrared (similar to a television's remote control) to open the valve.
Because the drugs pass through cheek tissue, instead of the intestines and stomach, the body has a better chance of absorbing the medicine.
The prosthetic tooth could be installed as part of a removable denture, a mouth guard, a bridge, an orthodontic bracket, or a dental implant, depending on the person. For example, a compliant patient who needs intermittent drug delivery would be a good candidate for a removable device. But an elderly person with dementia might be better off with a fixed one~~